xxxHolic was conceived when the group Clamp wanted to link the supernatural and fantasy series they made with a realistic one. This idea was further worked with the creation of the character of YĆ«ko Ichihara who would bridge the stories from xxxHolic and Tsubasa: Reservoir Chronicle.
The art style of the manga draws on the influence of ukiyo-e wood prints. When making a chapter composed of about twenty pages, Clamp takes around two days to make the artwork, the time differing with the ones from other series they made. The script of the series made by Nanase Ohkawa, who the other Clamp members ask her about any confusion they have before starting drawing the chapters. The illustrations and character designs are mainly done by Tsubaki Nekoi with assistance from Mokona although Satsuki Igarashi also draws various parts.