The band originated in Madrid with six members but the remaining three relocated to Mexico in 2001 after recording their first album Primera toma ("Take #1").
On March 16, 2007, the band performed for the first time at Mexico's most important venue, the National Auditorium (Auditorio Nacional), in Mexico City.
After seven years La Quinta Estación's guitarist, Pablo Domínguez, decided it was time for him leave te group and joined to Varsovia.La Quinta Estación's next studio album was released on March 3, 2009. The lead single is announced called ("Que Te Quería") and was released January 5, 2009.
The date of Sin Frenos, La Quinta Estacion's next CD, is March 17, 2009 for the US.
On February 20, 2010 Cadena Dial (a Spanish radio station) falsely announced the "exclusive" news of the final separation of La Quinta Estación, i.e. breaking the duo Angel and Natalia.
On November 12, 2010, day after the Latin Grammys, Natalia Jimenez said La Quinta Estacion will still exist and that the two are simply looking into individual projects, but "one day we will release another album (as La Quinta Estacion)".
